ABO Blood Types with Chi Square Analysis

Overview & Concepts

Students will read and review background information on the ABO blood groups and will practice blood type problems to ensure their understanding of multiple allele genetics.  Students will analyze blood types of the US population, make comparisons, and evaluate the significance using Chi Square analysis.

Grade Level: 

Concepts Covered: 

Genetics, ABO, blood typing, multiple alleles, chi square analysis, single nucleotide polymorphism (SNP)

Prior Knowledge Required: 

This lesson requires knowledge of basic biological concepts, including blood types and inheritance.

Activity Notes

Days to Teach: 

2 (48 minute periods)

Materials: 

worksheets (see attached documents), calculators

Teaching Tips / Activity Overview: 

  1. Introduce the lesson.
  2. Hand out "Blood Typing" reading and review questions.  
  3. Allow students to work in small groups or alone to read and review what blood type is, how it is determined, and the ABO blood groups including genotype.  
  4. Students should do the practice blood type problems to ensure their understanding of multiple allele genetics.
  5. After students complete the background work, hand out "Chi-Squared Analysis: Statistical Analysis of the US and Our Class Blood Types" worksheet.
  6. Collect class data, then allow students to work alone or in small groups to analyze blood types of the US population, make comparisons, and evaluate the significance using Chi Square analysis.

Assessment: 

Evaluate answers to blood type problems, understanding of chi square analysis,  and performanceon unit test.

Resources: 

Acknowledgements: 

This lesson was produced by Jamie Myers, adapted from Chapter 5 of Blood Groups and Red Cell Antigens by Laura Dean  and Chapter 2 of Modern Genetics for All Students p. 150-153.

Academic Standards
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