3.3C Describe and explain gene inheritance and expression at the molecular level.

Medical Problem Solving, Case 2: What is the Cause of the Seizures?

This activity is focused around a case study. Students use various data tools and data sets (including OMIM, pedigree analysis, 10K Microarray / SNP data and the Genome browser) to identify candidate genes.  After locating the gene, students use BLAST and BLAT to learn more about the type of mutation and normal function of the gene. Read more about Medical Problem Solving, Case 2: What is the Cause of the Seizures?

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Medical Problem Solving, Case 3: Pretzel Syndrome

In a case study-based context, students use microarray data and Chi-square analysis to determine the SNP that is likely causing the condition.  Students then determine the identity of the mutated gene, as well as the function of the normal gene and the type of mutation that causes the syndrome. Read more about Medical Problem Solving, Case 3: Pretzel Syndrome

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Eye Color: Is Blue Really Blue?

What determines eye color? After learning about different models of how eye color is determined, students will examine phenotypes from 16 subjects and predict if they have B (blue) or non-blue HERC2 gene. Next they will analyze PCR light cycler data and see if that matches their predictions. Read more about Eye Color: Is Blue Really Blue?

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Genetic Disorder Research

This lesson is a research activity on genetic disorders.  It emphasizes the use of Online Inheritance of Man (OMIM), as well as other genetic databases. The student will locate the gene or genes involved with a disorder, discuss symptoms, prevalence, and possible treatment and present this material to the class using Prezi (presentation tool). Read more about Genetic Disorder Research

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What is Cloning?

This is an introductory lesson on cloning.  It is a mini webquest that gives students an opportunity to learn about the different ways clones come about and then gives them the opportunity to participate in a somatic cell nuclear transfer in a virtual mouse.  Through this lesson, students will develop an understanding of cloning and the different techniques used to accomplish it.  After this l Read more about What is Cloning?

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Detecting a Transposon Tag in Arabidopsis

This lab - produced by the DNA Learning Center and available at http://www.greenomes.org/ - allows students to investigate a gene in Arabidopsis to analyze the molecular relationship between genotyes and phenotypes.  It also helps them understand the use of transposable elements to mutagenize and tag genes as well as the role of homeotic genes i Read more about Detecting a Transposon Tag in Arabidopsis

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