3.8 Science, Technology and Human Endeavors

Medical Problem Solving, Case 2: What is the Cause of the Seizures?

This activity is focused around a case study. Students use various data tools and data sets (including OMIM, pedigree analysis, 10K Microarray / SNP data and the Genome browser) to identify candidate genes.  After locating the gene, students use BLAST and BLAT to learn more about the type of mutation and normal function of the gene. Read more about Medical Problem Solving, Case 2: What is the Cause of the Seizures?

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Medical Problem Solving, Case 3: Pretzel Syndrome

In a case study-based context, students use microarray data and Chi-square analysis to determine the SNP that is likely causing the condition.  Students then determine the identity of the mutated gene, as well as the function of the normal gene and the type of mutation that causes the syndrome. Read more about Medical Problem Solving, Case 3: Pretzel Syndrome

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Eye Color: Is Blue Really Blue?

What determines eye color? After learning about different models of how eye color is determined, students will examine phenotypes from 16 subjects and predict if they have B (blue) or non-blue HERC2 gene. Next they will analyze PCR light cycler data and see if that matches their predictions. Read more about Eye Color: Is Blue Really Blue?

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DNA Surveillance Unit: Is That an Endangered Whale You’re Eating?

In order to better understand DNA fingerprinting and its real world applications, students will use a real genomic site, DNA Surveillance, based in New Zealand, to test whale samples against a standard database. This is done to monitor the sale of protected whale species in Japanese fish markets. Read more about DNA Surveillance Unit: Is That an Endangered Whale You’re Eating?

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Detecting a Transposon Tag in Arabidopsis

This lab - produced by the DNA Learning Center and available at http://www.greenomes.org/ - allows students to investigate a gene in Arabidopsis to analyze the molecular relationship between genotyes and phenotypes.  It also helps them understand the use of transposable elements to mutagenize and tag genes as well as the role of homeotic genes i Read more about Detecting a Transposon Tag in Arabidopsis

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Bioinformatics Using Basic Genomics Sequences

This activity will familiarize high school students on the importance of computational biology in today's world. By writing computer programs that use genomics sequence analysis, the student will have a better understanding of molecular biology and how the vast amount of data that is provided in multiple on-line databases can be simplified by a few lines of code. Read more about Bioinformatics Using Basic Genomics Sequences

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Decoding a DNA Sequence with Java

Students will write a Java program to read a DNA sequence from either the keyboard or a text file. Then they will display the protein sequence that is produced. Students will simulate the mutation of a single location in the DNA sequence to determine the effects of that mutation. Finally, students will look for the locations of a specific DNA sequence. Read more about Decoding a DNA Sequence with Java

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