Grade 10

Who Dunnit? The Case of the Missing Laptop

The Case of the Missing Laptop is designed to be used as a unit.  It begins with a story about a petty high school crime and some DNA evidence found at the crime scene.  Students are taken through a problem-solving process as they learn techniques that would help them assess the DNA evidence from the crime scene to identify the perpetrator. Read more about Who Dunnit? The Case of the Missing Laptop

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Using Bioinformatics to Solve Medical Problems: An HIV Case Study

Using an activity published by Beloit College at bioquest.org, students will develop an understanding of how bioinformatics allows us to solve problems. Students will analyze data to determine if a dentist was the source of the HIV transmitted to a patient(s).  Read more about Using Bioinformatics to Solve Medical Problems: An HIV Case Study

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Modes of DNA Analysis: Extraction, Electrophoresis, PCR, and Microarray

Students will develop an understanding of available technologies that assist in analyzing DNA. Students will work virtually though the processes of DNA extraction, PCR, Gel electrophoresis, and DNA microarrays. Virtual extraction and electrophoresis labs will be used to show students the process before they actually do the process themselves. Read more about Modes of DNA Analysis: Extraction, Electrophoresis, PCR, and Microarray

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The Central Dogma of Biology: DNA to Protein

The Central Dogma activity provides students practice in the transcription and translation of a small segment of an actual gene in the human body.  Students then use BLASTn to identify their sequence as well as the program CN3D to view 3-D models of their protein.  The activity concludes with the connection between mutation and disease as students investigate the cond Read more about The Central Dogma of Biology: DNA to Protein

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As easy as one, two, pee: A study of Alkaptonuria

This lesson introduces students to the Orina family.  Carlos, a member of the Orina family, has been diagnosed with a genetic disease called Alkaptonuria, which makes a person's urine turn dark black.  During this lesson, students first take on the role of a geneticist and use the OMIM database to prepare a one-page summary sheet that could be presented to the Orina family with information abo Read more about As easy as one, two, pee: A study of Alkaptonuria

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Molecular Conservation & Evolutionary Relationships

Students attempt to determine how sequences are used as evolutionary tools to determine relative age of relationship of organisms. Students are given sections of DNA and amino acid sequences and asked to determine differences between them. In part 1, students work with online DNA sequences found on BLAST. In part 2, students use paper based amino acid sequences. Read more about Molecular Conservation & Evolutionary Relationships

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