Grade 9

Canine Case Studies: Using Pedigrees and DNA Sequencing to Solve Problems

Dogs and genetics meet in two case studies that encourage students to be detectives.  In the first case study, students will use a pedigree to solve a problem about a genetic disorder in a specific dog breed.  In the second case study, students will use maps, graphs, and DNA sequencing to determine what animal “meat” is being used in two different brands of dog food.   Read more about Canine Case Studies: Using Pedigrees and DNA Sequencing to Solve Problems

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Bacteria Primer Comparison 2: Gel Electrophoresis

This lesson will occur after a lesson in which the students will isolate bacterial DNA by using primers and PCR. In this lesson, each student will be able to accept or reject his or her hypothesis by completing gel electrophoresis of the PCR product and analyzing the results compared to the other bacterial primer products and a ladder.   Read more about Bacteria Primer Comparison 2: Gel Electrophoresis

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Bacteria Primer Comparison 1: PCR

This lesson will allow students to become familiar with the PCR process by using the thermocycler after discussing the process and its purpose along with completing an online simulation of it.  It will also allow the students to hypothesize which primer will work best with the various prokaryotic samples and then analyze their results after researching basic characteristics about the bacteria Read more about Bacteria Primer Comparison 1: PCR

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Blue People of Kentucky

In this activity students will be introduced to an unusual and rare genetic condition that causes a person's skin to turn blue.   A powerpoint presentation will be used to introduce the topic.  The presentation will open up opportunities to review genetic concepts as well as create discussion on topics like population genetics, ethics, etc.  Students will examine a pedigree where they will see Read more about Blue People of Kentucky

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In the Year 2525… Using Real Time PCR Data to Analyze a Founder Scenario

This activity will place the concepts of Hardy-Weinberg equilibrium into a contemporary context.  During the activity students will interpret data from real-time PCR and use it to calculate allele frequencies.  These allele frequencies will then serve as a hypothetical founder population, for which students will run simulations using Allele A1 software to predict possible future allele frequen Read more about In the Year 2525… Using Real Time PCR Data to Analyze a Founder Scenario

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Who Dunnit? The Case of the Missing Laptop

The Case of the Missing Laptop is designed to be used as a unit.  It begins with a story about a petty high school crime and some DNA evidence found at the crime scene.  Students are taken through a problem-solving process as they learn techniques that would help them assess the DNA evidence from the crime scene to identify the perpetrator. Read more about Who Dunnit? The Case of the Missing Laptop

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The Central Dogma of Biology: DNA to Protein

The Central Dogma activity provides students practice in the transcription and translation of a small segment of an actual gene in the human body.  Students then use BLASTn to identify their sequence as well as the program CN3D to view 3-D models of their protein.  The activity concludes with the connection between mutation and disease as students investigate the cond Read more about The Central Dogma of Biology: DNA to Protein

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As easy as one, two, pee: A study of Alkaptonuria

This lesson introduces students to the Orina family.  Carlos, a member of the Orina family, has been diagnosed with a genetic disease called Alkaptonuria, which makes a person's urine turn dark black.  During this lesson, students first take on the role of a geneticist and use the OMIM database to prepare a one-page summary sheet that could be presented to the Orina family with information abo Read more about As easy as one, two, pee: A study of Alkaptonuria

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