Days to Teach:
Online research and worksheet ~40 minutes
Teaching Tips / Activity Overview:
- Students will link specific human genetic disorders to specific genes and types of mutations.
- Students will connect genes to protein function and provide potential medical treatments based on this relationship.
- Students will learn to use online databases such as OMIM and Genome Sequencer to find information relevant to specific genes and disorders.
- Students will use gene maps to locate specific genes of interest.
- Give students a list of human genetic disorders to choose from or assign them a human genetic disorder, but be sure that all disorders are caused by mutations in one or two single genes and are not due to nondisjunction. Possible human genetic disorders include but certainly are not limited to: sickle cell anemia, fragile x syndrome, autism, achondroplasia, cystic fibrosis, thalassemia, hemophilia, color blindness, Duchenne muscular dystrophy, hemochromatosis, Marfan syndrome, neurofibromatosis, Huntington's disease, Parkinson's disease, phenylkentonuria, Type 1 gluteric acidemia, osteogenesis imperfecta, progeria, Tay-Sachs, and severe combined immunodeficiency.
- Hand out the Human Genetic Disorders student sheeet (see attachments) and allow students to work through it.
- Students may have difficulty initially locating their gene's position in the Genome Browser gene map. The gene of interest is indicated by a red marking along the map.