In this case study activity, students read about a disease in the Mennonite population and learn more about the disorder using OMIM. Students will also be introduced to SNP analysis to visualize how the gene that is causing a disorder is found. Students will also get the opportunity to see how mutations can be determined and the effect of these mutations. Read more about Medical Problem Solving using OMIM
DNA, RNA, Genetics and Genomics
Bioinformatics-based lessons are a powerful way to guide students to a deep and comprehensive study of genetics. The lessons in our collection span all levels of biology, from “seeing” DNA, to using gene sequences to identify and learn about genetic diseases, to analyzing PCR data in order to answer complex questions.
This series of lessons is designed to introduce students to PCR - its function and the process. Read more about mtDNA Amplification and Comparison
This activity is designed to provide students with a greater depth of understanding of the causes of human genetic disorders. It will also take students through an exploration of the processes that can be used by physicians and geneticists on quest for medical diagnoses and treatments by utilizing various online databases. Read more about Investigating Human Genetic Disorders
A daughter thinks she’s adopted and wants to determine if her parents are her biological parents. Students discover how gel electrophoresis is used to help the daughter determine if she is adopted or not. In addition, students apply previously learned material (pedigree, Punnett square, etc.) to help understand the process and content. Read more about Determining Relationships in Families using Gel Electrophoresis
This activity is designed to introduce students to The Online Mendelian Inheritance in Man (OMIM) database. Students will start by analyzing a patient's symptoms and correctly identifying the genetic disorder that is causing the problem. Finally, the student will use OMIM to gather information about that specific genetic disorder. Read more about OMIM......Oh My: Using The Online Mendalian Inheritance and Man Database
Students will use their understanding of Mendelian genetics and real-time PCR assays to determine the parental identity for each of the mixed up babies. Read more about A Mix-Up in the Nursery
Is it a case of food poisoning? Your students will have to figure out the cause of a man's illness. After reading a mini case study, students will analyze the remains of the sub sandwhich to determine if there are prokaryotic organisms that caused the illness. Students will use PCR analysis and gel electrophoresis. Read more about What Was In That Sandwich?
Students will use the NCBI BLAST site and OMIM to identify an “unknown” gene and then determine conservation of this gene, disorders/symptoms caused by mutations in this gene, and gene locus on the map viewer. Read more about BLAST that Gene
Teaching Bioinformatics Using Journals is an acivity designed to help students learn the real world applications of bioinformatics and current research in genomics. It also gives students the opportunity to learn how to read a scientific journal. After completing this activity students will have several strategies to read and better understand a scientific journal. Read more about Teaching Bioinformatics Using Journals
Online activities, videos, and hands-on labs allow students to visualize and practice bioengineering techniques and concepts in this week-long unit. Students will learn about DNA extraction, restriction enzymes, gel electrophoresis, PCR, and DNA sequencing by answering a series of questions based on videos, diagrams, and prior knowledge. Read more about A Student-Centered Guide to Bioengineering