Medical Problem Solving

Have your students explore authentic medical scenarios and apply bioinformatics and cutting-edge genetics in a health context relevant to everyone. Medical problem solving activities combine basic biological concepts with higher order thinking skills, empowering each student to be a problem-solver.

Medical Problem Solving, Case 2: What is the Cause of the Seizures?

This activity is focused around a case study. Students use various data tools and data sets (including OMIM, pedigree analysis, 10K Microarray / SNP data and the Genome browser) to identify candidate genes.  After locating the gene, students use BLAST and BLAT to learn more about the type of mutation and normal function of the gene. Read more about Medical Problem Solving, Case 2: What is the Cause of the Seizures?

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Medical Problem Solving, Case 3: Pretzel Syndrome

In a case study-based context, students use microarray data and Chi-square analysis to determine the SNP that is likely causing the condition.  Students then determine the identity of the mutated gene, as well as the function of the normal gene and the type of mutation that causes the syndrome. Read more about Medical Problem Solving, Case 3: Pretzel Syndrome

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Medical Problem Solving using OMIM

In this case study activity, students read about a disease in the Mennonite population and learn more about the disorder using OMIM.  Students will also be introduced to SNP analysis to visualize how the gene that is causing a disorder is found.  Students will also get the opportunity to see how mutations can be determined and the effect of these mutations. Read more about Medical Problem Solving using OMIM

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OMIM......Oh My: Using The Online Mendalian Inheritance and Man Database

This activity is designed to introduce students to The Online Mendelian Inheritance in Man (OMIM) database.  Students will start by analyzing a patient's symptoms and correctly identifying the genetic disorder that is causing the problem.  Finally, the student will use OMIM to gather information about that specific genetic disorder. Read more about OMIM......Oh My: Using The Online Mendalian Inheritance and Man Database

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Using Bioinformatics to Solve Medical Problems: An HIV Case Study

Using an activity published by Beloit College at bioquest.org, students will develop an understanding of how bioinformatics allows us to solve problems. Students will analyze data to determine if a dentist was the source of the HIV transmitted to a patient(s).  Read more about Using Bioinformatics to Solve Medical Problems: An HIV Case Study

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As easy as one, two, pee: A study of Alkaptonuria

This lesson introduces students to the Orina family.  Carlos, a member of the Orina family, has been diagnosed with a genetic disease called Alkaptonuria, which makes a person's urine turn dark black.  During this lesson, students first take on the role of a geneticist and use the OMIM database to prepare a one-page summary sheet that could be presented to the Orina family with information abo Read more about As easy as one, two, pee: A study of Alkaptonuria

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The Importance of Anatomy and Physiology in Understanding Symptoms

Desgined for use early in an Anatomy and Physiology course, this presentation shows students how an understanding of systems interactions is used by medical professionals to diagnosis different disorders. This lesson introduces OMIM, Online Mendelian Inheritance in Man, a database that collects information on diseases and disorders. Read more about The Importance of Anatomy and Physiology in Understanding Symptoms

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