Teaching Tips / Activity Overview:
Introduction: Genetic disease- What do you know?
- Have students write at least 3 things they know about genetic diseases. Allow students to share their answers and conduct a brief class discussion.
- Briefly review genes and mutations. Explain how mutations cause genetic disease. Provide a brief overview of genetic disease, some quick explanations of various diseases.
- You can also show a short video clip on genetic disease. See the Extensions section.
Identifying disease genes activity:
- Group students as you wish. They can work in pairs or in small groups.
- Hand out student instruction sheet and demo on board how to use genetic information (genes-DNA) to link to a specific genetic disease
- Give students their nucleotide BLAST sequence cards to use to determine the name of their genetic disorder.
- Students will navigate various websites to find information asked on the student hand out.
- Share what each group has learned:
- After all students are finished, call the group together and have students share what they learned about the diseases.
- Alternatively, each group could prepare a short formal 3-4 minute Prezi or Powerpoint presentation on the disease and its manifestation. Or students can design an informative brochure about their genetic disorder.
- Students should work with partner so they are not overwhelmed by the information.
- Constant circulation and assistance will be needed, especially for the students’ first BLAST.
- Depending on your level of students, it might be helpful to do a review of different types of inheritance.