How can we identify genes associated with human genetic disorders using online biological databases? Students will be given the nucleotide sequence that links with a human genetic disorder. Read more about Researching Genetic Disorders Using BLAST
After reading a case study about a child with a disease, students search OMIM, use the NSBI Map Viewer, and work with 10K Microarray data to identify a disease and find the gene that’s causing it. SNPs and Microarrays are explained in the activity. Read more about Medical Problem Solving, Case 1: A Genetic Link to Anemia
The webquest uses the same story and data as Case 1, but differs in approach. Students take on the roles of a doctor and a geneticist at The Clinic for Special Children. Together, they follow the steps of the webquest to diagnose and treat a young boy. Read more about Medical Problem Solving Webquest
This activity is focused around a case study. Students use various data tools and data sets (including OMIM, pedigree analysis, 10K Microarray / SNP data and the Genome browser) to identify candidate genes. After locating the gene, students use BLAST and BLAT to learn more about the type of mutation and normal function of the gene. Read more about Medical Problem Solving, Case 2: What is the Cause of the Seizures?
In a case study-based context, students use microarray data and Chi-square analysis to determine the SNP that is likely causing the condition. Students then determine the identity of the mutated gene, as well as the function of the normal gene and the type of mutation that causes the syndrome. Read more about Medical Problem Solving, Case 3: Pretzel Syndrome
What determines eye color? After learning about different models of how eye color is determined, students will examine phenotypes from 16 subjects and predict if they have B (blue) or non-blue HERC2 gene. Next they will analyze PCR light cycler data and see if that matches their predictions. Read more about Eye Color: Is Blue Really Blue?
This lesson is a research activity on genetic disorders. It emphasizes the use of Online Inheritance of Man (OMIM), as well as other genetic databases. The student will locate the gene or genes involved with a disorder, discuss symptoms, prevalence, and possible treatment and present this material to the class using Prezi (presentation tool). Read more about Genetic Disorder Research
This is an introductory lesson on cloning. It is a mini webquest that gives students an opportunity to learn about the different ways clones come about and then gives them the opportunity to participate in a somatic cell nuclear transfer in a virtual mouse. Through this lesson, students will develop an understanding of cloning and the different techniques used to accomplish it. After this l Read more about What is Cloning?
This is an introductory lesson to DNA. It involves an activity that gives students an opportunity to examine real human DNA they extract from the inside of their mouths. Through this engaging activity, students will develop an understanding of DNA as a real, tangible substance. Students will take notice of how their observations from the investigation are different or consistent with thei Read more about DNA Detectives: Extract your Own DNA
This lesson is the 1st in a unit on constructing Phylogenetic Trees from DNA or Protein Sequences. Students build an Excel spreadsheet to model the simplest implementation of the LCS (Longest Common Subsequence) algorithm in order to calculate the degree of homology between 2 sequences. Read more about Phylogenetic Trees, Part 1: Pairwise Alignment of Related DNA / Protein Sequences using the LCS Algorithm