Genomics

Medical Problem Solving, Case 2: What is the Cause of the Seizures?

This activity is focused around a case study. Students use various data tools and data sets (including OMIM, pedigree analysis, 10K Microarray / SNP data and the Genome browser) to identify candidate genes.  After locating the gene, students use BLAST and BLAT to learn more about the type of mutation and normal function of the gene. Read more about Medical Problem Solving, Case 2: What is the Cause of the Seizures?

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Medical Problem Solving, Case 3: Pretzel Syndrome

In a case study-based context, students use microarray data and Chi-square analysis to determine the SNP that is likely causing the condition.  Students then determine the identity of the mutated gene, as well as the function of the normal gene and the type of mutation that causes the syndrome. Read more about Medical Problem Solving, Case 3: Pretzel Syndrome

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Detecting a Transposon Tag in Arabidopsis

This lab - produced by the DNA Learning Center and available at http://www.greenomes.org/ - allows students to investigate a gene in Arabidopsis to analyze the molecular relationship between genotyes and phenotypes.  It also helps them understand the use of transposable elements to mutagenize and tag genes as well as the role of homeotic genes i Read more about Detecting a Transposon Tag in Arabidopsis

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Bioinformatics Using Basic Genomics Sequences

This activity will familiarize high school students on the importance of computational biology in today's world. By writing computer programs that use genomics sequence analysis, the student will have a better understanding of molecular biology and how the vast amount of data that is provided in multiple on-line databases can be simplified by a few lines of code. Read more about Bioinformatics Using Basic Genomics Sequences

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Investigating Human Genetic Disorders

This activity is designed to provide students with a greater depth of understanding of the causes of human genetic disorders. It will also take  students through an exploration of the processes that can be used by physicians and geneticists on quest for medical diagnoses and treatments by utilizing various online databases. Read more about Investigating Human Genetic Disorders

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OMIM......Oh My: Using The Online Mendalian Inheritance and Man Database

This activity is designed to introduce students to The Online Mendelian Inheritance in Man (OMIM) database.  Students will start by analyzing a patient's symptoms and correctly identifying the genetic disorder that is causing the problem.  Finally, the student will use OMIM to gather information about that specific genetic disorder. Read more about OMIM......Oh My: Using The Online Mendalian Inheritance and Man Database

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